The Andean white-eared opossum (Didelphis pernigra ) is an opossum species from South America. It is found in the Andes Mountains, ranging from Venezuela to Bolivia.
Together with the Guianan white-eared opossum (D. imperfecta ), this species was separated from the white-eared opossum (D. albiventris ) in 2002, having been included with that species in 1993.